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HypoPara Life Impacts Assessment

“It is important that we seek support as we navigate this disorder.” – Andrea, living with HypoPara.
Compensated by Ascendis Pharmaceuticals.

Managing Your HypoPara

Woman with HypoPara getting coffee with a friend Woman with HypoPara getting coffee with a friend

Active Vitamin D and Calcium Are Used to Address Calcium Levels in the Absence of PTH

PTH Gland Icon


The main hormone that controls calcium and phosphate levels (forms bones and teeth) as well as other actions in the body

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Oral Calcium

Addresses low calcium levels

Vitamin D Icon

Active Vitamin D

Helps the body absorb calcium

With active vitamin D and calcium:

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Calcium levels may have to be checked

2 Calcium Pills Icon

Many pills may be required to maintain
calcium levels

Calcium intake from diet and antacids
may also affect calcium levels

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Signs and symptoms of HypoPara may
still occur

Woman with HypoPara talking to a friend
PTH Gland Icon

With the right levels of PTH, calcium levels are under control without the need for additional medication.

Over Time, Missing PTH May Have Serious Consequences

Severe high and low calcium levels may still occur with active vitamin D and calcium. These episodes are hard to predict and could require emergency attention.

Woman with HypoPara experiencing the “calcium rollercoaster” Woman with HypoPara experiencing the “calcium rollercoaster” Woman with HypoPara experiencing the “calcium rollercoaster”
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Symptoms of low blood calcium levels


Depression, anger, confusion or brain fog, seizures


Abnormal heart rate, symptoms of congestive heart failure (such as fatigue, weakness)


Abdominal cramps


Lack of breath, wheezing, throat tightness


Numbness and a pins-and-needles feeling in the fingers and toes, spasms, twitches, cramps

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Signs of high blood calcium levels


Weakness, headache, drowsiness, confusion or disorientation, poor memory, reduced concentration


Abnormal heart rate, high blood pressure


Loss of appetite, nausea, vomiting, abdominal pain, constipation


Frequent urination, dry mouth, thirst

Calcium deposits can build up in organs, which may lead to complications over time

Some affected areas of the body include the:

Brain Icon


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Kidneys Icon


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Blood vessels

*Calcium deposits in the kidneys, kidney stones, and chronic kidney disease are mostly the result of treatment with active vitamin D and calcium rather than of HypoPara itself.

Signs That Your HypoPara May Not Be Fully Addressed


Low calcium levels may lead to ER visits and symptoms such as muscle cramps and seizures


Stomach issues may affect how calcium is absorbed


Kidney issues (such as high levels of calcium in urine)


Reduced physical functioning and well-being (such as fatigue, brain fog)


Frequent increases in doses of active vitamin D and calcium


High phosphate levels can contribute to the buildup of calcium in organs over time

Taking Active Vitamin D and Calcium May Have Increased Risks of Complications

Increased risk of:


Kidney stones*


Poor kidney function*


Hospital stays due to seizures

*Kidney stones and poor kidney function are mostly the result of treatment with active vitamin D and calcium rather than of hypoparathyroidism itself.


In a survey, 79% of people had hospital stays and emergency care visits due to HypoPara-related issues.

A survey of 374 participants analyzed the hardships associated with hypoparathyroidism with a focus on the clinical and social impacts on quality of life. Questions in the survey included input from clinical experts, patients, and the HypoPARAthyroidism Association and were approved by the Institutional Review Board of the University of Mississippi. The average duration of the disease was 12.6 years. Calcium, either alone or in combination with other medications (including active vitamin D), was used by 92% of the study participants.

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Understand HypoPara

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Ca2+=calcium; ER=emergency room; HypoPara=hypoparathyroidism; PTH=parathyroid hormone.